Table 1. Expression of TIGIT and PD-1 on ATL cells and HTLV-1 infected CD4+ T cells.* .
Disease Type | TIGIT- PD1- | TIGIT+ PD1- | TIGIT- PD1+ | TIGIT+ PD1+ |
---|---|---|---|---|
ATL #1 (c) | 0.06 | 0.61 | 1.91 | 97.4 |
ATL #2 (c) | 7.38 | 4.38 | 19.6 | 68.6 |
ATL #3 (c) | 0.31 | 21.3 | 0.15 | 78.3 |
ATL #4 (a) | 51.2 | 39.8 | 2.66 | 6.38 |
ATL #5 (a) | 2.69 | 1.76 | 1.76 | 93.8 |
HAM/TSP #1 | 17.8 | 18.9 | 12.0 | 51.3 |
HAM/TSP #2 | 34.5 | 30.2 | 14.3 | 21.1 |
HAM/TSP #3 | 13.2 | 19.9 | 15.6 | 51.2 |
HAM/TSP #4 | 18.1 | 13.6 | 12.6 | 55.7 |
HAM/TSP #5 | 20.8 | 24.1 | 11.9 | 43.2 |
Healthy donors | 75.3 ± 8.91 | 3.09 ± 1.05 | 13.8 ± 3.73 | 7.89 ± 4.44 |
*For acute ATL cases, the numbers indicate the percentage of CD3lowCD4+ ATL cells in each category. For HAM/TSP cases, the numbers indicate the percentage of CD4+CADM1+ T cells. In healthy donors, the numbers indicate the percentage of CD4+ T cells. The mean percentages (± SD) from 4 donors are shown for healthy donors.
(a): acute ATL,
(c): chronic ATL.