Table 2.

Clinical characteristics of T2R in three different patients

	Case 1	Case 2	Case 3
Symptoms	Fever, abdominal pain, nasal stuffiness, back pain	Joint/extremity swelling, nodular rash (initially), neuritis	Fever, new painful skin lesions
Exam findings	Abdominal tenderness, no rash	Joint swelling, erythematous lesions on back	Hypotension, diffuse nodular, tender rash, enlarged tender inguinal lymphadenopathy
Laboratory findings	ESR: > 120 mm/hour	CRP: 28.67 mg/L	Creatinine: 1.8 mg/dL
	CRP: 10.82 mg/dL	WBCs: 5,600 cells/mL	ALT: 90 IU/L
	WBCs: 2,900 cells/mL	Creatinine: 1.3 mg/dL	AST: 119 IU/L
	Normal creatinine	Normal liver enzymes	WBCs: 23,400 cells/mL
	Normal liver enzymes		Na: 124 mmol/L
Radiographic findings	Abdominal CT: reactive mesenteric lymphadenopathy and hypodense splenic lesions	N/A	N/A
Treatment	Prednisone	Prednisone and thalidomide	Prednisone → thalidomide
Clinical course	Recurrence after 2 years with abdominal pain	Stable on low-dose prednisone and thalidomide after first recurrence	No recurrence after starting thalidomide

ALT = alanine aminotransferase; AST = aspartate aminotransferase; CRP = C-reactive protein; CT = computed tomography; ESR = erythrocyte sedimentation rate; N/A = not applicable; Na = sodium; T2R = type 2 reaction; WBCs = white blood cells.