Table 3. PROVEAN and SIFT predictions of the functional consequences of the Nrf2 amino acid replacements in Old World fruit bats.
| No. | Variant in Nrf2 protein | Domain | PROVEAN predictions | SIFT predictions | ||
|---|---|---|---|---|---|---|
| PROVEAN Score | Predicted effects on Nrf2 protein (cutoff = -1.3)a | SIFT Score | Predicted effects on Nrf2 protein (cutoff = 0.05)b | |||
| 1 | A100D | — | -0.600 | Neutral | 0.32 | Neutral |
| 2 | N133D | Neh4 | -0.936 | Neutral | 0.33 | Neutral |
| 3 | D205F | — | -3.378 | Deleterious | 0.01 | Deleterious |
| 4 | D224G | Neh7 | 0.047 | Neutral | 0.30 | Neutral |
| 5 | T279I | Neh7 | -1.797 | Deleterious | 0.14 | Neutral |
| 6 | T350R | Neh6 | -1.826 | Deleterious | 0.01 | Deleterious |
| 7 | N424S | — | 0.314 | Neutral | 0.44 | Neutral |
a Positions with PROVEAN Score less than -1.3 are predicted to be deleterious, while those greater than -1.3 are neutral.
b Positions with SIFT Score less than 0.05 are predicted to be deleterious, while those greater than 0.05 are neutral.