Fig 3.

Stochastic simulation realization [47] of viral load dynamics resulting from a single day’s latent cell activations for (a-b) drug efficacy ε = 0.9, associated with R = 0.23 and mean viral load V ₀ ≈ 4 copies/mL, and (c) ε = 0.6, associated with R = 0.92 and mean viral load V ₀ ≈ 38 copies/mL. In (a) we show the time span of a single day, to illustrate a single day’s dynamics, while in (b-c) we show dynamics until the lineages created by all activations from a single day, die out. Note that in each case, the latent cell activations occur at the same time. The latent reservoir decay rate η ₂ = log(2)/44 months and aL ₀ is chosen so that the on-therapy quasi-steady state viral load is V ₀ = 3.1 copies/mL assuming baseline drug efficacy ε = 0.99, infected cell death rate δ = 1 day⁻¹, and latency fraction f = 10⁻⁴.