Table 4.
IP group metabolic measures preconception vs pregnancy and preconception vs postpartum
| Characteristic | Preconception | Pregnancy | Preconception vs pregnancy |
Postpartum | Preconception vs postpartum |
|---|---|---|---|---|---|
| p | p | ||||
| Body composition | |||||
| Weight, kg | 59.7 (53.5–85.6) | 77.2 (62.9–94.3) | 0.003 | 61.7 (54.9–89.1) | 0.100 |
| FFM, kg | 42.5 (39.0–49.2) | 54.7 (46.7–57.5) | 0.003 | 44.3 (38.8–49.6) | 0.400 |
| Fat mass, kg | 20.7 (13.7–37.4) | 24.2 (14.9–38.7) | 0.100 | 18.4 (13.8–41.3) | 0.200 |
| Body fat, % | 30.0 (24.1–43.8) | 30.6 (24.8–40.2) | 0.400 | 29.3 (25.2–46.2) | 0.400 |
| Insulin response, pmol/ml×min | |||||
| 1st phase | 1,472 (1,229–2,188) | 3,563 (1,577–4,598) | 0.003 | 1,500 (972–2,834) | 0.300 |
| 2nd phase | 9,181 (7,799–11,911) | 21,002 (18,397–36,350) | 0.003 | 8,265 (4,910–14,744) | 0.700 |
| Total response | 11,459 (9,230–13,696) | 24,273 (19,981–40,218) | 0.003 | 11,522 (5,882–17,404) | 0.900 |
| Insulin sensitivity, mg (kg FFM)−1min−1 | 0.12 (0.06–0.13) | 0.06 (0.04–0.08) | 0.003 | 0.11 (0.10–0.15) | 0.100 |
| BEGP, mg (kg FFM)−1min−1 [n=7] | 2.86 (2.79–3.00) | 3.37 (2.73–3.90) | 0.100 | 3.03 (2.80–3.42) | 0.200 |
| Indirect calorimetry | |||||
| Basal metabolic rate, kJ min−1 FFM | 0.092 (0.092–0.105) | 0.100 (0.096–0.105) | 0.070 | 0.096 (0.088–0.096) | 0.500 |
| Carbohydrate oxidation, mg min−1 FFM | 2.67 (1.69–3.53) | 2.80 (2.26–3.69) | 0.500 | 2.18 (1.65–3.31) | 0.500 |
| Fat oxidation, mg min−1 FFM | 0.89 (0.67–1.03) | 1.09 (0.62–1.38) | 0.300 | 1.03 (0.65–1.31) | 0.500 |
| Indirect calorimetry, robust | |||||
| Basal metabolic rate, kJ/min | 4.23 (3.68–4.72) | 5.06 (4.44–6.32) | 0.003 | 4.06 (3.43–5.06) | 0.300 |
| Carbohydrate oxidation, mg/min | 117.3 (83.8–161.0) | 146.0 (114.0–179.0) | 0.080 | 97.7 (75.9–145.1) | 0.300 |
| Fat oxidation, mg/min | 38.3 (27.9–48.6) | 6.3 (33.1–73.5) | 0.080 | 43.1 (31.2–63.9) | 0.500 |
All values are median (IQR)