Skip to main content
. Author manuscript; available in PMC: 2016 Jan 6.
Published in final edited form as: Mol Cell. 2015 Mar 19;57(6):1110–1123. doi: 10.1016/j.molcel.2015.02.016

Figure 6. Hypothesized conformational switching scheme in the yybP-ykoY riboswitch.

Figure 6

In the absence of Mn2+, the riboswitch is in equilibrium between the undocked and docked conformation, controlled by the critical inter-helical A-minor interaction. Solution Mg2+ moderately stabilizes the docked conformation by mediating the L1-L3 interaction at MA site. Mn2+ binding to MB significantly stabilizes the L1-L3 interface, shifting the equilibrium toward the docked conformation.