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. 2016 Jan 6;11(1):e0141159. doi: 10.1371/journal.pone.0141159

Fig 4. Effects of rapamycin on the splenic lymphoid tissue in portal hypertensive rats.

Fig 4

(A) Representative histological images of spleen tissues stained with H&E (original magnification ×40) and immunostained for Ki67 (original magnification ×100). Arrowheads point to Ki67-positive cells. (B) Representative images of western blot for caspase 3 and caspase 7. (C) Quantitative analysis of white pulp occupied area and Ki67-positive cells area to white pulp area. (D) Quantification of cleaved caspase 3 and caspase 7 protein expression relative to GAPDH. *: p<0.05 versus SHAM-VEH, **: p<0.05 versus BDL-VEH, ***: p<0.05 versus PPVL-VEH.