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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Pflugers Arch. 2015 Sep 23;468(1):43–58. doi: 10.1007/s00424-015-1736-y

Fig. 6. Reducing agents inhibit and oxidants enhance PASMC K+ current.

Fig. 6

Fig. 6

Fig. 6

Effect of intracellular oxidants and reducing agents on whole-cell potassium currents in rat pulmonary artery smooth muscle cells. A) Family of K+ currents elicited b voltage steps before (left) and after (middle) 5 min dialysis of oxidized glutathione (GSSG) and current-voltage relationship for mean (± SEM) potassium current in the presence or absence of 2mM GSSG (right). B) Series of K+ currents elicited by a repetitive voltage step from −70 to +70 mV, every 20s after start of dialysis of reduced glutathione (GSH) (left) and current-voltage relationship for mean (± SEM) potassium current in the presence or absence of 2mM GSH (right). Graphical representation of current-voltage relationships for mean (± SEM) potassium current in the presence or absence of C) 100µM co-enzyme Q10, D) 100µM duroquinone, E) 100µM diamide. 5A and 5B from [93], 5C-5E from [76], reproduced with permission