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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Psychopharmacology (Berl). 2015 Oct 12;233(1):99–109. doi: 10.1007/s00213-015-4092-x

Figure 1.

Figure 1

Stress-potentiated reinstatement is CB1R-dependent. Data represent mean active lever responses (± SEM) during 2-h extinction and reinstatement tests. Stress-potentiated reinstatement is observed when rats are exposed to a stressor, 15 min intermittent electric footshock stress (EFS) followed immediately by a subthreshold dose of cocaine (COC, 2.5 mg/kg, i.p.; **p<.01, compared to reinstatement). Stress-potentiated reinstatement is blocked by pre-treatment with the CB1R antagonist AM251 (1 (n=6), 3 (n=6) mg/kg, i.p.) 30 min prior to the reinstatement test (#p<.05 compared to Veh/EFS/COC).