. Author manuscript; available in PMC: 2017 Jan 1.

Published in final edited form as: Psychopharmacology (Berl). 2015 Oct 12;233(1):99–109. doi: 10.1007/s00213-015-4092-x

Table 3.

Effects of footshock stress on endocannabinoid content in subregions of the medial prefrontal cortex

	2-AG (nmol/g tissue)		AEA (pmol/g tissue)
	Control	Shock	Control	Shock
Anterior Cingulate	2.4 ± 0.6	5.6 ± 0.5	8.9 ± 0.9	19.3 ± 5.1
Prelimbic	11.0 ± 1.8	9.6 ± 1.5	7.1 ± 2.7	17.8 ± 5.4
Infralimbic	4.6 ± 0.7	5.5 ± 0.8	6.3 ± 1.0	16.8 ± 7.1

Data represented are mean concentrations of the endocannabinoids 2-arachidonylglycerol (2-AG; nmol/g tissue) and anandamide (AEA; pmol/g tissue) 15 min after termination of a 15 min-footshock (n=7) or in control rats (n=7). There was a significant effect of footshock stress on AEA levels across the 3 brain regions (p<.001). Footshock stress significantly increased 2-AG in the anterior cingulate cortex (p<.05) and levels of 2-AG in the prelimbic cortex are significantly higher than those in the anterior cingulate or infralimbic (p<.001).