Skip to main content
. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Proteomics. 2015 Nov 24;16(1):33–46. doi: 10.1002/pmic.201500171

Figure 1.

Figure 1

Effect of VEGF inhibitor (CBO-P11) on BLM-induced fibrotic response in mice. Mice treated with BLM (1 U/kg) in the presence or absence of CBO-P11 (0.3 mg/kg) or equal volumes of saline as control were euthanized at 28 days. (A) Representative immunohistochemical micrographs of treated mice lung tissue stained with H&E. (B) Calculated fibrosis score based on the histopathological assessment of H&E-stained slides. (C) Lung homogenate from treated mice was analyzed for soluble collagen levels by Sircol® Assay. (D) Lung homogenate from treated mice was analyzed for collagen III levels by Western blotting. Western blots were reprobed with β-actin antibody to confirm equal loading of the samples. The immunoblot signals were quantified by densitometry. Plots are mean ± S.E.M of five animals per group. *p < 0.05 versus nontreated control.