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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Leukemia. 2015 Aug 12;30(1):219–228. doi: 10.1038/leu.2015.222

Figure 5. BCL2 overexpression can rescue AUY922-induced apoptosis in JURKAT T-ALL cell line.

Figure 5

(a) JURKAT cells overexpressing BCL2, BCLXL or MCL1, or infected with a control vector, were treated with graded concentrations of AUY922 for 72 h. Cell viability values are shown as mean ± s.d. percentages of the untreated control value in triplicate experiments. (b) Western blot analysis to examine PARP cleavage in the specific JURKAT cells treated with AUY922. The cells were treated with the indicated concentrations of AUY922 or DMSO control (AUY922 0 nM) for 48 h, and subjected to immunoblot analysis with antibodies specific for PARP and α-tubulin. (c) Western blot analysis of specific JURKAT cells treated with the indicated concentrations of AUY922 or DMSO (AUY922 0 nM) for 16 h. (d) Western blot analysis of specific JURKAT cells treated with the indicated concentrations of AUY922 or DMSO (AUY922 0 nM) for 48 h.