Table 2.
A | B | C | D |
---|---|---|---|
High CTRA (%) | Low CTRA (%) | p-value | |
Age, median (range), years | 37 (21–59) | 44 (21–59) | 0.04 |
Age | 0.16 | ||
20–29 | 10 (26) | 6 (15) | |
30–39 | 13 (33) | 7 (18) | |
40–49 | 11 (28) | 18 (46) | |
50–59 | 5 (13) | 8 (21) | |
Sex | 0.65 | ||
Male | 18 (46) | 20 (52) | |
Female | 21 (54) | 19 (48) | |
Median income, 2000* | 32300 | 58257 | 0.02 |
Distance to transplant center | 0.58 | ||
<17 miles | 12 (33) | 9 (23) | |
17–55 miles | 7 (18) | 12 (33) | |
55–150 miles | 11 (28) | 9 (23) | |
>150 miles | 9 (23) | 9 (23) | |
KPS | 0.38 | ||
>=90 | 33 (84) | 28 (72) | |
<90 | 4 (10) | 6 (16) | |
Missing | 2 (6) | 5 (12) | |
Comorbid conditions | 0.17 | ||
No | 24 (62) | 18 (46) | |
Yes | 15 (38) | 21 (54) | |
BMI, median (range), kg/m^2 | 27 (18–51) | 26 (20–44) | 0.9 |
BMI, kg/m^2 | 0.68 | ||
0 < 18.5 | 2 (5) | 0 (0) | |
18.5 – 24.9 | 13 (33) | 12 (30) | |
25 – 29.9 | 16 (41) | 17 (44) | |
>=30 | 8 (21) | 10 (26) | |
SES | |||
High | 14 (36) | 25 (64) | 0.02 |
Low | 25 (64) | 14 (36) | |
Cytogenetics | 0.64 | ||
Good risk | 0 (0) | 1 (2) | |
Intermediate risk | 19 (48) | 18 (46) | |
Poor/adverse risk | 9 (24) | 12 (30) | |
Unknown | 11 (28) | 8 (20) | |
HLA match status | 0.95 | ||
Well matched | 23 (59) | 24 (62) | |
Partially matched | 10 (26) | 10 (26) | |
Mismatched | 6 (15) | 5 (13) | |
Race match (donor/recipient) | 0.87 | ||
Match | 32 (82) | 32 (82) | |
Mismatch | 3 (8) | 4 (10) | |
Unknown | 4 (10) | 3 (8) | |
Donor age, median (range), years | 37 (20–56) | 35 (21–56) | 0.97 |
Donor age at transplant, years | 0.48 | ||
18–29 | 14 (36) | 11 (28) | |
30–39 | 11 (28) | 17 (44) | |
40–49 | 10 (26) | 6 (15) | |
>=50 | 4 (10) | 5 (13) | |
Sex match (donor/recipient) | 0.78 | ||
Male/male | 13 (33) | 14 (36) | |
Male/female | 13 (33) | 9 (23) | |
Female/male | 5 (13) | 6 (15) | |
Female/female | 8 (21) | 10 (26) | |
CMV match (donor/recipient) | 0.71 | ||
Negative/negative | 14 (36) | 12 (33) | |
Negative/positive | 11 (28) | 14 (36) | |
Positive/negative | 6 (15) | 4 (10) | |
Positive/positive | 7 (18) | 9 (23) | |
Unknown | 1 (3) | 0 (0) | |
Year of transplant | 0.64 | ||
1995–1999 | 15 (38) | 13 (33) | |
2000–2004 | 24 (62) | 26 (67) | |
Conditioning regimen | 0.74 | ||
Bu + Cy +/− Other | 5 (12) | 7 (18) | |
Cy + TBI +/− other | 28 (72) | 26 (67) | |
TBI +/− other | 3 (8) | 1 (3) | |
Flu +/− other | 3 (8) | 4 (10) | |
Other | 0 (0) | 1 (3) | |
GVHD prophylaxis | 0.84 | ||
T-cell depletion | 7 (18) | 6 (15) | |
CSA + MTX +/− others | 17 (44) | 14 (36) | |
CSA +/− others | 1 (3) | 1 (3) | |
Tacrolimus + MTX | 12 (31) | 13 (33) | |
Tacrolimus | 2 (5) | 5 (12) | |
Graft type | 0.31 | ||
Bone marrow | 30 (77) | 26 (67) | |
Peripheral blood | 9 (31) | 13 (33) | |
Infused BM cell dose | 0.41 | ||
> 2 × 10^8 | 14 (47) | 15 (58) | |
<= 2 × 10^8 | 16 (53) | 11 (42) | |
Missing | 0 (0) | 0 (0) | |
Infused PB cell dose | 0.02 | ||
> 5 × 10^8 | 4 (44) | 11 (85) | |
<= 5 × 10^8 | 4 (44) | 0 (0) | |
Missing | 1 (11) | 2 (15) | |
Time from diagnosis to transplant, median (range), months | 6 (3–17) | 5 (3–15) | 0.28 |
Donor search time, median (range), months | |||
Diagnosis to preliminary search | 2 (<1–10) | 2 (<1–10) | 0.45 |
Preliminary search to formal search | <1 (0–12) | <1 (0–3) | 0.44 |
Formal search to transplant | 3 (2–8) | 3 (2–11) | 0.45 |
Follow-up of survivors, median (range), months | 28 (12–81) | 36 (23–132) | 0.52 |
Cause of Death | 0.18 | ||
Infection | 5 (13) | 5 (13) | |
Interstitial pneumonia | 3 (8) | 3 (8) | |
aGVHD | 3 (8) | 4 (10) | |
Recurrence or persistence of primary disease | 8 (21) | 1 (3) | |
Organ failure | 5 (13) | 5 (13) | |
Hemorrhage | 3 (8) | 1 (3) | |
Other | 12 (31) | 20 (51) |
BM, bone marrow; Bu, busulfan; CMV, cytomegalovirus; CSA, cyclosporine; CTRA, conserved transcriptional response to adversity; Cy, cyclophosphamide; Flu, fludarabine; GVHD, graft-versus-host disease; HLA, human leukocyte antigen; KPS, Karnofsky Performance Status; MTX, methotrexate; PB, peripheral blood; TBI, total body irradiation
Based on 2004 Census tract data linking income to residential ZIP code.