Table 2.

A. Functional capacity tests
Assessment scale	Description	Measured variable
2MWT	The patient is instructed to walk as fast as possible a 50-foot course (25-feet each direction) with 180 degree turns at each end, and the total distance covered in 2 minutes is recorded (80).	Functional status. Functional capacity.
HGS test	Grip strength using a portable electronic dynamometer three times in the dominant hand (average of 3 measurements) (82).	Functional status. Functional capacity.
PFTs	The LFS is calculated from theFEV1and DLCO corrected for hemoglobin. The FEV1 and DLCO are converted to a numeric score as follows: >80=1; 70% to 79%=2; 60% to 69%=3; 50% to 59%=4; 40% to 49%=5; and <40%=6. The LFS=FEV1 score + DLCO score, with a possible range of 2 to 12, with higher numbers indicating worse dysfunction. The LFS (0 to 3) is derived as follows: 0 = FEV1>80% or LFS 2; 1 = FEV1 60% to 79% or LFS 3 to 5; 2 = FEV1 40% to 59% or LFS 6 to 9; and 3 = FEV1<39% or LFS 10 to 12 (87). Portable spirometry serves torecord of FEV1 after the patient is instructed to take a deep breath and exhale forcefully and rapidly (3 measures), although formal pulmonary function testing is preferable if available.	Respiratory capacity. Lung capacity.
ROM	Using a standard goniometer in the supine position, participants' mean bilateral ROM measurements are converted to the percentage of normal ROM, using the American Academy of Orthopaedic Surgeons' definition of normal ROM for each joint: measurements that exceeded the maximum value are assigned a score of 100 and joints with fixed contractures are assigned a score of 0, and an aggregate score (125) is calculated representing the patient's average degree of impairment in upper and lower body ROM.	Joint/fascia response.
P-ROM scale	It is a series of images that captures ROM separately for shoulders, elbows, wrists/fingers, and ankles (83), with lower scores indicating more limited ROM. The P-ROM total score is the sum of scores in all 4 joints, with a maximum possible score of 25.	Joint/fascia response. ROM.

B. Patient’s self-reports of functional capacity and physical domain of quality of life (QoL).
Assessment scale	Description	Measured variable
HAP	It is a 94-item self-reported assessment of energy expenditure and physical fitness. Responders are asked to indicate, whether they are “still doing this activity”, “have stopped doing this activity”, or “never did this activity”. Two scores are calculated: the MAS, which is the number of the most difficult task the respondent is “still doing”, and the AAS, calculated by counting how many activities with lower values than the MAS the respondent has “stopped doing” and subtracting this from the MAS.	Daily activity. Physical functioning
SF-36	This tool is a 36-item self-report questionnaire that examines following domains: physical functioning, role limitations as a result of physical functioning, bodily pain, general health, vitality, social functioning, role emotional functioning, and mental health. These domains can be aggregated into 2 summary scales: the PCS and the MCS, both of them are derived by using a standard algorithm to aggregate scores across the eight domains (population mean of 50; standard deviation of 10). SF-36 higher scores indicate better functioning; lower scores on the PCS indicate limitations in physical functioning and role participation, a high degree of bodily pain, and an unfavorable perception of general health (126).	QoL. Functional health and well-being
FACT-BMT	It is a 37-item self-report questionnaire that measures the effect of cancer therapy on domains including physical, functional, social/family, and emotional well-being, and bone marrow transplantation concerns. Individual domain scores can be summarized to give a total FACT-BMT score (including all subscales) or a FACT-TOI (physical well-being + functional well-being + BMT subscale) (91).	QoL
L-cGVHD-SC	It is 30-item, 7-subscale symptom scale self-administered patient that evaluates adverse effects of cGVHD on skin, vitality (energy), lung, nutritional status, psychological functioning, muscles and joints, eyes, and mouth. A summary score is created by taking the mean of all items and linearly transforming that value to a 0–100 scale (79). We can find a muscle/ joint subscale which is a summary of 4 items, i.e., joint and muscle aches, limited joint movement, muscle cramps, and weak muscles, with each item rated as follows: 0 → not at all; 1 → slightly; 2 → moderately; 3 → quite a bit; 4 →extremely.	cGVHD symptom

C. National Institutes of Health specifics scales.
Assessment scale	Description	Measured variable
NIH joint/fascia score	It uses a 0–3-point scale. 0: no symptoms; 1: mild tightness of arms or legs, normal or mild decreased ROM, and not affecting ADL; 2: tightness of arms or legs or joint contractures, erythema thought due to fasciitis, moderate decrease in ROM, and mild-to-moderate limitation of ADL; 3: contracture with significant decrease of ROM and significant limitation of ADL (unable to tie shoes, button shirts, dress self, etc.)	Tightness. ROM. ADL.
NIH lung score	It uses a 0–3-point scale. 0: no symptoms; 1: shortness of breath with stairs; 2: shortness of breath on flat ground; and 3: shortness of breath at rest or requiring oxygen.	Pulmonary function.

Abbreviations:ADL, Activities of Daily Living; DLCO, Diffusing Capacity of Carbon Monoxide; FEV₁, Forced Expiratory Volume in 1 second; HGS, Hand Grip Strength; LFS, Lung Function Score; PFTs, Pulmonary Function Tests; P-ROM, Photographic-Range of Motion scale; ROM, Range of Motion; 2MWT, 2-Minute Walk Test.

Abbreviations: AAS, Adjusted Activity Score; cGVHD, chronic Graft-versus-Host disease;FACT-BMT, Functional Assessment of Cancer Therapy-Bone Marrow Transplant; FACT-TOI,Functional Assessment of Cancer Therapy–Trial Outcome Index; HAP, Human Activity Profile; L-cGVHD-SC, Lee cGVHD Symptom Scale; MAS, Maximum Activity Score;MCS, Mental Component Score; PCS, Physical Component Score; SF-36, Medical Outcomes Study 36-Item Short-Form Health Survey.

Abbreviations: ADL, Activities of Daily Living; NIH, National Institutes of Health; ROM, Range of Motion.