Fig. 3.

Male-female reciprocal social interaction parameters were increased in BTBR after ganaxolone treatment. a) Ganaxolone did not affect the reciprocal social interaction parameter of nose-to-nose sniffing in B6 mice. b) Ganaxolone (20 mg/kg) increased nose-to-nose sniffing in BTBR male mice. c) Ganaxolone did not affect nose-to-anogenital sniffing by B6 male mice. d) Ganaxolone (20 mg/kg) increased BTBR nose-to-anogenital sniffing of female stimulus mice. e) Ganaxolone did not affect nose-to-body sniffing by B6 male mice. f) Ganaxolone (20 mg/kg) increased BTBR nose-to-body sniffing of female stimulus mice. g) Ganaxolone did not affect total social sniffing by B6 male. h) Ganaxolone (20 mg/kg) increased BTBR total social sniffing of female stimulus mice. i) Ganaxolone did not alter the time engaged in exploring the arena during the reciprocal interaction session in B6 or BTBR mice. j) Ganaxolone had no significant effect on total cage exploration in male B6 or BTBR mice. *p<0.05, as compared to vehicle