Fig. 5.

Open field activity was increased by ganaxolone in BTBR but not B6 mice. a-d) Ganaxolone administration did not affect total distance travelled or horizontal activity in B6 mice. Ganaxolone increased total distance travelled (20 mg/kg) and horizontal activity (10 and 20 mg/kg) in BTBR mice. g-h) On the vertical activity parameters, ganaxolone (20 mg/kg) marginally decreased vertical activity in B6 mice. Ganaxolone did not significantly alter vertical activity in BTBR mice. i-j) Ganaxolone had no effect on center distance travelled in B6 mice. Ganaxolone (10 and 20 mg/kg) increased center distance travelled in BTBR mice. *p<0.05, #p<0.09, as compared to vehicle