Fig. 6.

Complex effects of ganaxolone on the elevated plus-maze. To compare the actions of ganaxolone on social and repetitive behaviors to previously reported effects on anxiety-related behaviors, ganaxolone was evaluated in B6 and BTBR mice in the elevated plus-maze. a-b) Ganaxolone did not significantly affect percent open arm time in B6 or BTBR mice. c-d) High doses of ganaxolone tended to increase open arm entries in B6 and significantly increased open arm entries in BTBR (20 and 30 mg/kg) mice. e-f) Ganaxolone administration (10-30 mg/kg) increased total entries in B6 and BTBR mice. Higher total arm entries, indicating more overall exploration, is consistent with findings in the social approach chamber (Fig. 1 and 2), and may confound the interpretation of specific anxiolytic-like effects of ganaxolone. *p<0.05, as compared to vehicle