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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Cancer Res. 2015 Dec 17;76(1):127–138. doi: 10.1158/0008-5472.CAN-15-0817

Figure 6. Mutations of gatekeeper residue blocks sensitivity to TNK2 inhibitors.

Figure 6

Addition of the T205I and T205M gatekeeper mutations to the D163E TNK2 mutations causes resistance to Dasatinib (A), XMD8-87 (B), XMD16-5 (C) and AIM-100 (D). Inhibitor studies were performed on IL-3 independent Ba/F3 lines as described in Figure 5. Parental Ba/F3 cells grown in IL3 containing medium were used as a control.