Table 2.
Differentially methylated regions (DMRs) identified in young male highlanders (18–25 years) born to women with hypertensive pregnancy (HTNPREG) versus normotensive controls
| DMR gene symbol genomic location | Ref gene feature(s) | Ref gene distance | Slk p‐value | Slk‐Sidak p‐value | Probes | deltaBeta |
|---|---|---|---|---|---|---|
| CTHRC1 Chr8: 104383714–104383798 | TSS, exon, 5’UTR | 0 | 9.82E‐07 | 0.006 | cg04219247 | –0.015 |
| cg20447655 | –0.040 | |||||
| cg20392240 | –0.017 | |||||
| cg11889769 | –0.024 | |||||
| cg21643403 | –0.033 | |||||
| LINC00226 * Chr14: 106806142–106806179 | intergenic | 61176 | 1.97E‐06 | 0.025 | cg23404902 | 0.038 |
| cg01842774 | 0.072 | |||||
| TRIM31 Chr6: 30071502–30071612 | intron | 0 | 8.55E‐08 | 0.0004 | cg00354641 | –0.034 |
| cg27123071 | –0.028 | |||||
| cg13436843 | –0.086 | |||||
| cg09735274 | –0.087 | |||||
| ARID1B * Chr6: 159983262–156983315 | intergenic | –115748 | 2.20E‐07 | 0.002 | cg05282260 | 0.047 |
| cg08839808 | 0.097 | |||||
| cg00269725 | 0.072 | |||||
| SMOC2 * Chr6: 169284284–169284344 | intergenic | 215610 | 1.81E‐08 | 0.001 | cg17720554 | 0.052 |
| cg10213762 | 0.087 | |||||
| cg12550496 | 0.100 | |||||
| LRRIQ3 Chr1: 74663582–74663750 | intron, exon, 5’UTR | 0 | 1.81E‐08 | 5.11E‐05 | cg16356856 | –0.106 |
| cg13900770 | –0.085 | |||||
| cg06034096 | –0.094 | |||||
| cg00402366 | –0.162 |
*Denotes hypermethylated genes; the remainder are hypomethlated. Genomic regions were defined according to the UCSC RefGene group. Intergenic = site not annotated in a gene; TSS = transcription start site at 200–1,500 bp; 5′ region = 5′UTR and 1st exon; Intragenic = gene body including introns and exons; 3′ region = 3′UTR; UTR = untranslated region. Individual sites that compose the differentially methylated regions and their percent methylation change are shown in the Probes and deltaBeta columns, respectively.