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. Author manuscript; available in PMC: 2016 Jan 6.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2014 Aug 23;90(3):554–561. doi: 10.1016/j.ijrobp.2014.06.058

Table 3.

Effect of increasing mean dose on cognitive test scores by brain volume. P-values are grouped in columns according to the inclusion (+) or exclusion (−) of age in the model.

Normal Tissue Volume Estimated IQ WIAT Math WIAT Reading WIAT Spelling
− + − + − + − +
Entire Brain 0.0121 <0.0001 0.0096 0.0007 n.s. <0.0001 n.s. 0.0002
Supratentorial Brain 0.0161 <0.0001 0.0251 0.0009 n.s. <0.0001 n.s. 0.0002
Temporal Lobe (Left) 0.0032 <0.0001 0.0184 0.0013 n.s. <0.0001 n.s. 0.0002
Temporal Lobe (Right) 0.0005 <0.0001 0.0053 0.0009 0.0184 <0.0001 n.s. <0.0001
Hippocampus (Left) 0.0751 <0.0001 n.s. 0.0025 n.s. <0.0001 n.s. 0.0001
Hippocampus (Right) 0.0130 <0.0001 n.s. 0.0016 n.s. <0.0001 n.s. <0.0001
Infratentorial Brain 0.0002 <0.0001 n.s. 0.0034 n.s. <0.0001 n.s. 0.0001
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