Table 3.
Metabolites with a significant unadjusted interaction with medication group on relative HbA1c change among patients with HbA1c > 6.5 %
| Metformin | Sulphonylurea (SU) | Metformin and SU | ||||
|---|---|---|---|---|---|---|
| Coefficient | p-value | Coefficient | p-value | Coefficient | p-value | |
| Glucose (HMDB 00122, CAS 50-99-7) | −2.7 | 0.0003 | −2.2 | 0.012 | −2.8 | 0.0002 |
| Glutamic acid internal amide (HMDB 00267, CAS 98-79-3) | 39.1 | 0.001 | 28.1 | 0.042 | 29.5 | 0.009 |
| 1,5 anhydroglucitol (HMDB 02712, CAS 154-58-5) | 23.7 | 0.003 | 21.2 | 0.018 | 42.4 | <0.0001 |
| 4-hydroxyglutamate semialdehyde (HMDB 06556) | 1327.7 | 0.007 | 1219.7 | 0.030 | 1180.1 | 0.018 |
| 2-hydroxybutanoic acid (HMDB 00008, CAS 5094-24-6) | −85.8 | 0.009 | −6.5 | 0.898 | −110.6 | 0.002 |
| 3-amino 2 piperinidon (HMDB 00323, CAS 1892-22-4) | −23.2 | 0.013 | −250.8 | 0.792 | −1535.5 | 0.023 |
| 3 hydroxybutanoic acid (HMDB 00357, CAS 300-85-6) | −23.2 | 0.013 | −39.4 | 0.297 | −58.3 | 0.012 |
| 4-oxoproline (KEGG C01877, CAS 4347-18-6) | 464.6 | 0.029 | 224.7 | 0.477 | 576.8 | 0.022 |
| 2-hydroxypiperidine (Pubchem 24847875, CAS 5382-16-1) | 1126.4 | 0.045 | 696.3 | 0.319 | 1283.3 | 0.033 |
| Xanthine (HMDB 00292, CAS 69-89-6) | 2086.6 | 0.501 | −4215.6 | 0.261 | −8405.6 | 0.004 |
| C20:1 fatty acid (HMDB 02231, CAS 26764-41-0) | −1590.6 | 0.103 | −1724.4 | 0.176 | −2701.4 | 0.009 |
| C14:0 fatty acid (HMDB 00806, CAS 544-63-8) | −267.3 | 0.243 | −219.4 | 0.534 | −527.4 | 0.026 |
| C18:0 fatty acid (HMDB 00827, CAS 57-11-4) | −804 | 0.231 | −27.1 | 0.771 | −145.8 | 0.030 |
| C17:0 fatty acid (HMDB 02259, CAS 506-12-7) | −1273.0 | 0.476 | 368.5 | 0.880 | −3742.5 | 0.039 |
| Mannose (HMDB 00169, CAS 3458-28-4) | −58.5 | 0.425 | −13.2 | 0.898 | −152.6 | 0.042 |
| LCB 18:1-17:0 SM | 1348.7 | 0.090 | 675.3 | 0.493 | 1702.6 | 0.043 |
| Myo-inositol (HMDB 00211, CAS 87-89-8) | 53.1 | 0.083 | −12.2 | 0.735 | 67.2 | 0.044 |
| LCB 18:0-16:0 SM (HMDB 10168) | 61.8 | 0.217 | 67.8 | 0.351 | 105.4 | 0.046 |
| Fumaric acid (HMDB 00134, CAS 110-17-8) | −979.8 | 0.266 | −2234.0 | 0.044 | −926.0 | 0.329 |