Fig. 5.

Myelin and fatty acid metabolism, myelin generation and repair, and inflammation related gene expression in reproductively aging female mice: A. Table depicting the fold change and p-value differences in expression of white matter related genes between reproductively irregular and reproductively incompetent female mice. Red p-value is indicative of upregulation while a green p-value indicates down regulation. Boxes outlined in red reached statistical significance. B. Heatmaps of gene expression organized by function: myelin and fatty acid metabolism, myelin generation and repair, and inflammation. Each gene was normalized and colored based on its relative expression level across 4 reproductive aging groups. This method allows genes that have different magnitude of signal intensity but which belong to the same functional group and share similar expression patterns to be displayed on the same heatmap. (N = 5 per group.)