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. 2016 Jan 7;5:103. doi: 10.3389/fcimb.2015.00103

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Copyright © 2016 Silva, Silva-Filho, Caruso-Neves and Pinheiro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed model of the inhibitory effect of Ang-(1–7) during P. falciparum invasion of human erythrocytes. 1, Ang II is converted to Ang-(1–7) by ACE 2 activity; 2, Ang-(1–7) binds its specific receptor; Mas, which is expressed in the human erythrocyte membrane; 3, a signaling pathway is triggered inhibiting PKA activity; 4, decreased PKA activity impairs merozoite invasion in the erythrocytes.