Table 2.
Pharmacokinetic parameters of enrofloxacin and ciprofloxacin in intestinal contents after oral administration of enrofloxacin at 10 mg/kg BW to broilers.
| PK parameters (units) | Healthy model |
Infected model |
||||
|---|---|---|---|---|---|---|
| ENR | CIP | ENR + CIP | ENR | CIP | ENR + CIP | |
| AUC (μg h/mL) | 206.30 | 18.63 | 228.97 | 406.74 | 31.39 | 444.86 |
| Tmax (h) | 1.18 | 5.50 | 1.23 | 1.06 | 6.09 | 1.13 |
| Cmax (μg mL−1) | 21.07 | 1.11 | 21.69 | 30.88 | 1.46 | 31.69 |
| V/F (mL/kg) | 413.02 | 4967.17 | 403.45 | 296.59 | 4392.84 | 289.02 |
| Cl/F (mL/h/kg) | 48.47 | 536.84 | 43.67 | 24.58 | 318.52 | 22.48 |
| Ka (h−1) | 2.79 | 0.28 | 2.72 | 3.66 | 0.31 | 3.43 |
| Ke (h−1) | 0.12 | 0.11 | 0.11 | 0.08 | 0.07 | 0.08 |
| T1/2e (h) | 5.91 | 6.41 | 6.40 | 8.36 | 9.56 | 8.91 |
| T > MIC | 39.29 | 30.08 | 42.79 | 49.89 | 43.59 | 49.95 |