Table 4.
Overrepresented gene ontology biological process annotations associated with differential expression of selected messenger RNAs using the DAVID tool
| Term | Count | Fold | p |
|---|---|---|---|
| GO0035556: intracellular signaling cascade | 10 | 2.3 | 0.0091 |
| GO0042981: regulation of apoptosis | 9 | 2.9 | 0.0036 |
| GO0043067: regulation of programmed cell death | 9 | 2.8 | 0.0039 |
| GO0001654: eye development | 8 | 12.3 | <0.001 |
| GO0007423: sensory organ development | 8 | 7 | <0.001 |
| GO0009888: tissue development | 8 | 2.8 | 0.0076 |
| GO0043065: positive regulation of apoptosis | 6 | 3.9 | 0.004 |
| GO0043068: positive regulation of programmed cell death | 6 | 3.9 | 0.0042 |
| GO0010942: positive regulation of cell death | 6 | 3.9 | 0.0043 |
| GO0043627: response to estrogen stimulus | 5 | 7.3 | <0.001 |
Database for Annotation, Visualization and Integrated Discovery (DAVID) tools were used for gene ontology (GO) analysis. Results show the top 10 GO terms that are significantly overrepresented (fold change > 2 and p < 0.01, Fisher's exact test) in the selected messenger RNAs of retinas of rats with diabetes.