Table 1.

Association of basic characteristics, clinical parameters, and genetic variation in CYP1A2, CYP2A6, CYP2B6, CYP3A4, CYP3A5, UGT2B7, ABCB1, NR1I2, and NR1I3 with median efavirenz plasma concentration.

Basic characteristics or clinical parameters					N	Median EFV conc. (μg/mL)	P-value
					222	2.56 (0.04-34.40)
Gender	Male				54 (0.25)	2.445	0.9288
	Female				167 (0.75)	2.590
Age					218	2.575	0.6040
Smoking	Yes				17 (0.08)	1.880	0.2877
	No				201 (0.92)	2.590
Alcohol consumption	Yes				24 (0.11)	1.865	0.0150
	No				194 (0.89)	2.640
BMI at baseline					192	2.615	0.0886
Disease stage	1				128 (0.59)	2.555	0.2217
	2				5 (0.02)	1.640
	3				66 (0.31)	2.670
	4				17 (0.08)	2.990
Concurrent treatment of tuberculosis	Yes				14 (0.13)	3.480	0.3361
	No				90 (0.87)	2.505
Gene	SNP ID	SNP position	Genotype	Genotype frequency N (freq)
CYP1A2	rs762551*	c.9-154C>A	C/C	35 (0.12)	26	3.180	0.2734
			C/A	151 (0.53)	114	2.640
			A/A	101 (0.35)	76	2.270
	rs45564134	c.974delG	G/G	202 (0.77)	150	2.505	0.8789
			G/- and -/-	62 (0.23)	50	2.735
CYP2A6	rs28399454*	c.1093G>A	G/G	253 (0.86)	190	2.615	0.1920
			G/A and A/A	40 (0.14)	32	2.175
CYP2B6	rs35303484*	c.136A>G	A/A	248 (0.84)	187	2.540	0.7802
			A/G	33 (0.11)	27	2.660
			G/G	14 (0.05)	8	3.095
	rs4803419*	c.485-18C>T	C/C	247 (0.89)	188	2.640	0.0045
			C/T and T/T	30 (0.11)	23	1.840
	rs3745274*	c.516G>T	G/G	107 (0.36)	79	1.970	<0.0001
			G/T	133 (0.45)	100	2.510
			T/T	55 (0.19)	43	7.490
	rs2279343*	c.785A>G	A/A	110 (0.38)	81	1.940	<0.0001
			A/G	132 (0.45)	100	2.510
			G/G	51 (0.17)	40	7.695
	rs28399499*	c.983T>C	T/T	253 (0.87)	192	2.395	<0.0001
			T/C	32 (0.11)	21	3.620
			C/C	5 (0.02)	5	21.80
	rs707265	c.1355A>G	A/A	15 (0.05)	14	2.590	0.7919
			A/G	75 (0.29)	54	2.630
			G/G	172 (0.66)	130	2.520
	rs1042389	c.1421T>C	T/T	174 (0.63)	133	2.970	0.0065
			T/C	90 (0.32)	64	2.190
			C/C	15 (0.05)	10	2.270
CYP3A4	rs2740574*	c.-392G>A	G/G	146 (0.51)	109	2.560	0.8630
			G/A	121 (0.42)	91	2.550
			A/A	21 (0.08)	16	2.570
CYP3A5	rs776746*	c.219-237G>A	G/G	7 (0.02)	5	7.020	0.1855
			G/A	77 (0.26)	58	2.805
			A/A	211 (0.72)	159	2.400
	rs10264272*	c.624G>A	G/G	195 (0.67)	148	2.590	0.5989
			G/A and A/A	96 (0.33)	72	2.515
	rs41303343*	c.1035_1036insT	–/–	282 (0.96)	215	2.550	0.6810
			–/T and T/T	12 (0.04)	6	2.590
	rs15524*	c.14T>C	T/T	37 (0.13)	29	2.770	0.2638
			T/C	114 (0.39)	90	2.670
			C/C	144 (0.49)	103	2.280
UGT2B7	rs7668258	c.-161T>C	T/T	15 (0.07)	14	2.775	0.2885
			T/C	75 (0.34)	58	2.385
			C/C	133 (0.60)	96	2.595
ABCB1	rs1128503*	c.1236T>C	T/C and T/T	60 (0.21)	42	2.730	0.1504
			C/C	235 (0.79)	180	2.470
	rs2032582*	c.2677G>T/A	G/G	283 (0.96)	215	2.560	0.3387
			G/A and G/T	10 (0.04)	7	2.470
	rs1045642*	c.3435T>C	T/C and T/T	62 (0.21)	43	2.470	0.6126
			C/C	233 (0.79)	179	2.560
	rs3842*	c.193A>G	A/A	189 (0.64)	140	2.670	0.1378
			A/G	96 (0.33)	75	2.220
			G/G	10 (0.03)	7	3.160
NR1I2 (PXR)	rs2472677*	c.96-7659C>T	C/C	97 (0.36)	68	2.660	0.8439
			C/T	133 (0.50)	102	2.555
			T/T	36 (0.14)	28	2.445
	rs3732356*	c.448+72G>T	G/G	10 (0.03)	6	4.710	0.7447
			G/T	123 (0.42)	99	2.680
			T/T	162 (0.55)	117	2.390
	rs6785049*	c.912-93G>A	G/G	264 (0.95)	199	2.560	0.9249
			G/A and A/A	14 (0.05)	11	2.480
	rs3732360	c.522C>T	C/C	123 (0.45)	93	2.590	0.1552
			C/T	115 (0.42)	87	2.600
			T/T	36 (0.13)	23	2.130
	rs1054190	c.659C>T	C/C	195 (0.90)	152	2.545	0.9843
			C/T and T/T	22 (0.10)	19	2.600
	rs1054191	c.838G>A	G/G	195 (0.72)	152	2.655	0.1553
			G/A and A/A	77 (0.28)	55	2.380
	rs3814057	c.1195A>C	A/A	43 (0.22)	43	2.480	0.3185
			A/C	108 (0.54)	108	2.630
			C/C	49 (0.24)	49	2.340
NR1I3 (CAR)	rs2307424*	c.540C>T	C/C	270 (0.91)	208	2.575	0.6195
			C/T	25 (0.09)	14	2.510
	rs2502815*	c.239-99C>T	C/C	180 (0.61)	144	2.505	0.2412
			C/T	100 (0.34)	65	2.770
			T/T	15 (0.05)	13	2.140
	rs3003596*	c.239-1089T>C	T/T	53 (0.18)	39	2.150	0.1365
			T/C	140 (0.48)	104	2.515
			C/C	100 (0.34)	78	2.805

P < 0.001 were considered significant and are shown in bold.

^*Genotype-phenotype associations were previously reported by Swart et al. (2012a), Swart et al. (2012c), Swart et al. (2013), and Evans et al. (2015).