Table 1.
Pathological lesions in brain tissue of Rift Valley fever virus (RVFV)-infected Lewis rats.
Day euthanized | # Rats displaying pathology | Description of pathological lesions |
---|---|---|
1 | 0/3 | None |
2 | 0/3 | None |
3 | 0/3 | None |
4 | 2/4 | Focal mild lymphocytic meningitis |
5 | 1/4 | Focal meningeal thickening |
6 | 3/3 | Lymphocytic meningitis; vasculitis containing lymphocytes, histiocytes, and neutrophils; focal cortical apoptosis; focal RVFV Ag+ cells in cortex |
7 | 3/3 | Lymphocytic meningitis; vasculitis containing lymphocytes, histiocytes, and neutrophils; apoptosis of the subcortical neurons; extensive RVFV Ag+ cells in cortex |