Table 3.
PAE durations of cefquinome against MRSA-M4 after a single dose of administration in catheter-associated biofilm infection model of mice.
| Cefquinome (mg/kg) | T > MIC (h) | T > MBIC(h) | PAE duration (h) |
|
|---|---|---|---|---|
| Planktonic† | Biofilm∗ | |||
| 8 | 1.9 | – | 0.6 | – |
| 16 | 3.1 | 0.28 | 0.9 | -0.5 |
| 32 | 4.8 | 0.47 | 1.8 | -0.2 |
| 64 | 6.0 | 0.75 | 2.3 | 0.6 |
| 128 | 8.7 | 3.16 | 3.8 | 0.3 |
| 256 | 11.5 | 4.38 | 5.3 | 0.7 |
†A positive relationship between cefquinome dosing and PAEs in planktonic cells (R2 = 94.9%); *P < 0.01 for PAEs of MRSA biofilm versus planktonic cells.