Table 4.
Integration of PK/PD indices of cefquinome against planktonic and biofilm bacteria in S. aureus catheter-associated biofilm infection model of mice (MRSA-M4).
| Cefquinome (mg/kg) | Planktonic |
Biofilm∗ |
||||
|---|---|---|---|---|---|---|
| T > MIC | Cmax/MIC | AUC/MIC | T > MBIC | Cmax/MBIC | AUC/MBIC | |
| 2 | 1.2 | 6.1 | 3.6 | – | 0.19 | 0.11 |
| 8 | 1.9 | 20.2 | 12.5 | – | 0.63 | 0.39 |
| 16 | 3.1 | 44.5 | 23.6 | 0.28 | 1.39 | 0.74 |
| 32 | 4.8 | 71.1 | 45.4 | 0.47 | 2.22 | 1.42 |
| 64 | 6.0 | 134.3 | 75.8 | 0.75 | 4.20 | 2.37 |
| 128 | 8.7 | 357.1 | 330.3 | 3.16 | 11.2 | 10.3 |
| 256 | 11.5 | 575.1 | 662.2 | 4.38 | 17.9 | 20.7 |
∗P < 0.05 for PK/PD indices of biofilm versus planktonic cells.