Table 5.
PK/PD model parameter estimates and target values of cefquinome for T > MIC or MBIC required to achieve the various antibacterial efficacies against a representative MRSA isolates M4 in planktonic or in catheter-associated biofilm infection model.
| Parameters and cell type | Emax† (log10 CFU/mL) | E0 (log10 CFU/mL) | EC50 (h) | Static (h) | 0.5-log10 drop (h) | 1.0-log10 drop (h) |
|---|---|---|---|---|---|---|
| Planktonic (T > MIC) | –5.64 | 3.11 | 6.61 | 7.25 | 8.61 | 10.4 |
| Biofilm (T > MIC)∗∗ | –4.40 | 2.16 | 17.4 | 17.6 | 19.7 | 22.7 |
| Biofilm (T > MBIC)∗ | –3.57 | 2.13 | 5.42 | 6.17 | 7.35 | 8.76 |
†Emax is the maximal drug effect of cefquinome against biofilm bacteria; E0, difference in number of biofilm bacteria (CFU/mL) in untreated group between time 0 and 24 h; EC50 is the T > MIC or MBIC value required to achieve 50% of the Emax; ∗P < 0.05 for T > MBIC in biofilm versus in planktonic cells; **P < 0.01 for T > MIC in biofilm versus in planktonic cells.