Table 6.
In vivo pharmacokinetics and pharmacodynamics model of cefquinome against a S. aureus catheter-associated biofilm infection using AUC24h/MBIC as the predictive PK-PD index (all study S. aureus strains included).
| Biofilm PK-PD Parameters (units) | Mean values | SD |
|---|---|---|
| Emax (log10 CFU/mL)† | –3.31 | 0.17 |
| E0 (log10 CFU/mL) | 1.95 | 0.09 |
| EC50 (h) | 20.3 | 0.15 |
| Slope (N) | 3.92 | 0.79 |
| AUC24h/MBIC for biofilm-static action (h) | 22.8 | 1.46 |
| AUC24h/MBIC for 1-log10-unit biofilm-cidal action (h) | 35.6 | 5.74 |
†Emax is the maximal drug effect of cefquinome against biofilm bacteria; E0, difference in number of biofilm bacteria (CFU/mL) in untreated group between time 0 and 24 h; EC50 is the AUC24h/MBIC value required to achieve 50% of the Emax; N, slope of AUC24h/MBIC-response curve; AUC24h/MBIC for biofilm-static action, values which produced E = 0 (no change in bacterial count after 24 h treatment).