Table 1.
Summary table of the effects of antidepressants on Cx43 expression and gap junctional function in astrocytes.
| Antidepressant | Class | Effect on Cx43 expression | Effect on Cx43 function | Model | Treatment (dose and time) | Reference |
|---|---|---|---|---|---|---|
| Amitriptyline | TCA | Increase (mRNA, protein) | Increase (gap junction) | Primary cultures rat cortical astrocytes | 25 μM, 48 h | Morioka et al., 2014 |
| Clomipramine | TCA | Increase (protein) | NT | Primary culture rat cortical astrocytes | 10 μM, 48 h | Morioka et al., 2014 |
| Fluoxetine | SSRI | Increase (protein) | NT | Rat in vivo Prefrontal cortex | 20 mg/kg i.p. for 21 days | Fatemi et al., 2008 |
| Fluoxetine | SSRI | Increase (mRNA, protein) | NT | Human astrocytoma cell line | 10, 20 μg/ml 24 h | Mostafavi et al., 2008 |
| Fluoxetine | SSRI | Increase (protein) | No effect (gap junction) | Rat in vivo Prefrontal cortex | 10 mg/kg 21 days | Sun et al., 2012 |
| Duloxetine | SNRI | Increase (mRNA, protein) | No effect (gap junction) | Rat in vivo Prefrontal cortex | 10 mg/kg 21 days | Sun et al., 2012 |
| Fluvoxamine | SSRI | Increase (protein) | NT | Primary cultures rat cortical astrocytes | 25 μM 48 h | Morioka et al., 2014 |