Table 2.

Summary table of the effect of seven antidepressants for four different classes: tricyclic (TCA), selective serotonin reuptake inhibitor (SSRI), noradrenaline reuptake inhibitor (NRI), serotonin noradrenaline reuptake inhibitor (SNRI), on Cx43 expression and channel functions in cultured astrocytes.

Antidepressant	Class	Concentration tested (μM)	Cx43 expression	Effect on gap junctional coupling	Effect on hemichannels
Amitriptyline	TCA	20	No significant effect	Inhibition	Mild inhibition
Imipramine	TCA	20	No significant effect	No effect	Mild inhibition
Fluoxetine	SSRI	10	No significant effect	Inhibition	Total inhibition
Paroxetine	SSRI	5	No significant effect	Increase	Total inhibition
Reboxetine	NRI	10	No significant effect	No effect	Mild inhibition
Duloxetine	SNRI	5	No significant effect	No effect	Total inhibition
Venlafaxine	SNRI	5	No significant effect	Inhibition	Mild inhibition