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. 2015 Dec 21;6:10130. doi: 10.1038/ncomms10130

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Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

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Network Analysis for EFEMP1 and WT1 was carried out using the RNA-seq FPKM>30 gene list (see Methods section). WT1 regulates many extracellular matrix genes, including MMP2 (matrix metalloproteinase-2) and CTGF (connective tissue growth factor). EFEMP1 directly interacts with ELASTIN, a component of elastic fibres in the ECM. TIMP3 (tissue inhibitor of metalloproteinase-3), which is activated by WT1 and interacts with EFEMP1 and was found to connect between the two networks.