Table 1. SNP associations reaching genome-wide significance in the combined analysis of discovery and replication cohorts.
| SNP | Chr. | Position | Gene | Risk allele |
Discovery |
Replication |
Combined |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
(5,295 cases, 67,510 controls) |
(9,701 cases, 82,743 controls) |
OR (95% CI) | P-value | |||||||||
| RAF | OR (95% CI) | P-value | RAF | OR (95% CI) | P-value | |||||||
| rs2009262 | 2 | 56,012,214 | EFEMP1 | T | 0.78 | 1.23 (1.17–1.30) | 3.66 × 10−15 | 0.78 | 1.10 (1.06–1.15) | 3.65 × 10−06 | 1.15 (1.11–1.19) | 1.45 × 10−17 |
| rs370763 | 5 | 64,355,060 | ADAMTS6 | A | 0.65 | 1.14 (1.09–1.19) | 9.70 × 10−09 | 0.67 | 1.06 (1.02–1.09) | 3.02 × 10−03 | 1.09 (1.06–1.12) | 3.73 × 10−9 |
| rs6991952 | 8 | 25,707,412 | EBF2 | G | 0.43 | 1.14 (1.10–1.19) | 1.17 × 10−10 | 0.43 | 1.08 (1.05–1.12) | 2.04 × 10−06 | 1.11 (1.08–1.14) | 6.68 × 10−15 |
| rs3809060 | 11 | 32,458,807 | WT1 | G | 0.62 | 1.18 (1.13–1.23) | 4.69 × 10−14 | 0.63 | 1.07 (1.03–1.10) | 1.69 × 10−04 | 1.11 (1.08–1.14) | 3.69 × 10−14 |
Chr., chromosome; CI, confidence interval; RAF, risk allele frequency; SNP, single-nucleotide polymorphism.