Table 2. Sex-stratified analysis of direct and indirect inguinal hernia among GERA discovery cohort.
| SNP | Inguinal Hernia Type |
Men |
Women |
Combined |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | ORF | PF | ORR | PR | I2 | PHet | ||
| rs2009262 | Direct | 1.25 (1.16–1.36) | 2.31 × 10−8 | 1.42 (1.04–1.94) | 0.03 | 1.26 (1.17–1.36) | 2.81 × 10−9 | 1.26 (1.17–1.36) | 2.81 × 10−9 | 0 | 0.46 |
| Indirect | 1.21 (1.13–1.31) | 4.48 × 10−7 | 1.51 (1.18–1.93) | 0.001 | 1.24 (1.15–1.33) | 8.48 × 10−9 | 1.31 (1.07–1.60) | 0.009 | 62.4 | 0.1 | |
| rs370763 | Direct | 1.14 (1.06–1.22) | 1.60 × 10−4 | 1.22 (0.94–1.58) | 0.133 | 1.14 (1.07–1.22) | 6.38 × 10−5 | 1.14 (1.07–1.22) | 6.38 × 10−5 | 0 | 0.65 |
| Indirect | 1.15 (1.08–1.23) | 2.86 × 10−5 | 1.10 (0.91–1.34) | 0.332 | 1.14 (1.08–1.22) | 2.28 × 10−5 | 1.14 (1.08–1.22) | 2.28 × 10−5 | 0 | 0.66 | |
| rs6991952 | Direct | 1.21 (1.14–1.29) | 8.95 × 10−10 | 1.03 (0.81–1.30) | 0.814 | 1.20 (1.13–1.28) | 2.38 × 10−9 | 1.16 (1.01–1.34) | 0.044 | 46 | 0.17 |
| Indirect | 1.14 (1.08–1.21) | 1.17 × 10−5 | 1.07 (0.89–1.28) | 0.461 | 1.14 (1.07–1.20) | 1.20 × 10−5 | 1.14 (1.07–1.20) | 1.20 × 10−5 | 0 | 0.46 | |
| rs3809060 | Direct | 1.21 (1.13–1.29) | 2.71 × 10−8 | 1.44 (1.11–1.86) | 0.006 | 1.22 (1.14–1.30) | 1.55 × 10−9 | 1.26 (1.09–1.46) | 0.003 | 44.7 | 0.18 |
| Indirect | 1.17 (1.09–1.24) | 2.16 × 10−6 | 1.55 (1.26–1.89) | 2.41 × 10−5 | 1.20 (1.13–1.27) | 8.14 × 10−9 | 1.32 (1.00–1.74) | 0.051 | 85.9 | 0.01 | |
CI, confidence interval; GERA, Genetic Epidemiology Research in Adult Health and Aging; I2, heterogeneity index; ORF, odds ratio from fixed effects model; ORR, odds ratio from random effects model; PHet, P value for heterogeneity from Cochran's Q test; PF, P value from fixed effects model; PR, P value from random effects model; SNP, single-nucleotide polymorphism.