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. 2015 Dec 16;6:10186. doi: 10.1038/ncomms10186

Figure 8. SRF–YAP–IL6 signalling is upregulated in basal-type breast cancer.

Figure 8

(a,b) SRF–YAP/TAZ–IL6 are highly expressed BLBC. (a) Heatmap analysis (b) and statistical analysis of the expression of the indicated genes in a panel of breast cancers (GSE31448; n>27 for each subtype). (c,d) A tissue microarray of breast cancers was stained with antibodies against the indicated proteins. (c) Representative immunohistochemical data for different types of breast cancers. Scale bar, 100 μm. (d) Summary and statistical analysis of tissue microarray data. P values were calculated using Fisher's exact test. (e) Scatter plot of signature score for the indicated cell types against YAP+TAZ or SRF expression levels (n=357; correlation tested using Pearson's correlation coefficient, r). (f) Scatter plot of IL6 and CTGF expression against YAP+TAZ or SRF expression levels (n=357; correlation tested using Pearson's correlation coefficient, r). Data are presented as means±s.e.m. (**P<0.01, ***P<0.001, NS, not significant (P>0.05), Student's t-test used in all analyses).