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| CL (L/h/kg) | V (L/kg) | |
|---|---|---|
| Reference PK parameters in neonates | 0.016 (0.005-0.029) | 1.03 (0.76- 1.37) |
| Extrapolation from juvenile animal | ||
| CL | ||
| Weight normalized CL | 0.076 | |
| Simple allometry | 0.528 | |
| Simple allometry with corrected factor of MLP | 0.016 | |
| V | ||
| Weight normalized V | 0.91 | |
| Simple allometry | 0.09 | |
| Extrapolation from adult | 0.014 | 0.80 |
| Extrapolation from PBPK model | 0.016 | 0.96 |
Values are expressed as median (range)
