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. Author manuscript; available in PMC: 2016 Jan 7.
Published in final edited form as: Clin Pharmacokinet. 2014 Nov;53(11):1005–1018. doi: 10.1007/s40262-014-0169-7

Table 5. Predicted and reference AUC0-24h values at steady-state in neonates with the loading dose regimen [Piper L et al., 2011].

AUC at steady state (mg•h/L) PE (%)
Prediction Median (5th-95th)
Juvenile mice 766 (541, 1098) -2.2
Adults 862 (442, 1596) 10.1%
PBPK 747 (406, 1595) -4.6%
Observation
Neonates 783 (403, 2300)
Target value 800