Table 6. Genotypes in MDRTBplus and MDRsl results to detect RIF, INH, FLQ, KAN and EMB resistance in 14 drug-resistant TB cases.
| Drug Resistance | Resistance and GTplus & GTsla pattern |
CSF Samples n (%) |
||||
|---|---|---|---|---|---|---|
| Gene and Analyzed Codons | WTb | MUTc | Mono-drug resistance (n = 8) | MDR TB (n = 4) | Resistance to more than one drug (n = 2) | |
| Resistance to RIF | 2 (28.6) | 4 (57.1) | 1 (14.3) | |||
| rpoB518-525 | Δ6 (S522Q) | 1 (14.3) | 3 (42.9) | 1 (14.3) | ||
| rpoB530-533 | Mut3 (S531L) | 1 (14.3) | 1 (14.3) | 0 | ||
| Resistance to INH | 6 (54.6) | 4 (36.4) | 1 (9.1) | |||
| High level | katG 315 | Mut1 (S315T1) | 6 (54.6) | 4 (36.4) | 1 (9.1) | |
| Low level | inhA | 0 | 0 | 0 | ||
| Resistance to FLQ | 0 | 1 (50.0) | 1 (50.0) | |||
| GyrA92-97 | Mut3C (D93G) | 0 | 1 (50.0) | 1 (50.0) | ||
| Resistance to EMB | 0 | 0 | 2 (100) | |||
| embB306 | Mut1B (M306V) | 0 | 0 | 2 (100) | ||
aGTplus, the GenoType MTBDRplus Assay; GTsl, the GenoType MTBDRsl assay.
bWT, wild-type pattern with all respective bands; Δwt, omission of the respective wild-type band.
cMUT, mutations corresponding to the specific mutation probes in the tested gene.