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. 2016 Jan 7;6:18934. doi: 10.1038/srep18934

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(a) Inhibition of TCR/CD28 induced NF-κB signaling by iNUB. Primary murine CD4+ T-cells were incubated with iNUB (20 μM, 40 μM) or DMSO and co-stimulated with anti-CD3/anti-CD28 antibodies. IκBα phosphorylation was detected by Western Blotting. (b,c) iNUB inhibits NF-kB target gene expression in primary T-cells. CD4+ T-cells were treated as in (a,b) IL-2 expression was analyzed on mRNA level by qPCR after 3 h as well as on protein levels by ELISA after 20 h and (c) TNFAIP3/A20, TNFα, NFKBAI/IκBα and INFγ mRNA expression was analyzed after 3 h (n = 3; +/− SD).