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Specificity of SpsB for the signal-peptide C region. (a) Surface representation contoured to show the S1 and S3 pockets, which contain Ala side chains at P1 and P3 of the peptide. The peptide inhibitor Pep3 (yellow) is shown in its 2F o − F c electron density contoured at 1.0σ, with its C-region residues labelled P1–P6 and P1′–P3′ (mature protein portion). The catalytic serine and lysine residues are in cyan adjacent to the cleavage site (marked with an asterisk).
