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. 2016 Jan 1;3(Pt 1):51–60. doi: 10.1107/S2052252515021259

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© Bauman et al. 2016

This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.

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Hidden-pocket identification. Hidden pockets are shown for (a) influenza endonuclease, (b) proteinase K, (c, d) the HIV-1 RT nucleic acid-binding cleft, (e) the RT Knuckles site and (f) the RT NNRTI Adjacent site. (a, b) The positions of the apo residues are colored magenta and the bound form green. Major changes in positions are indicated with black arrows. (c, d) Electrostatic potential surface for the nucleic acid-binding cleft in RT–rilpivirine without (c) and with (d) 4-bromopyrazole. The location of the NNRTI Adjacent pocket is indicated. (e, f) The positions of the apo residues are colored magenta, the bound form green and the nucleic acid-bound form [in (f) only] cyan.