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Predicted residue stability using COREX/BEST. The predicted residue stabilities of (a) c4 (black) and c4-3G (red) and (b) c4-3hx in acidic (black) and basic (red) conditions are shown. These stabilities are based on the ratio of the summed probabilities of the states in the ensemble in which a particular residue is in a folded conformation to the summed probability of the states in which a residue is in an unfolded conformation. Arrowheads indicate fusion/linker sites.
