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. Author manuscript; available in PMC: 2016 Jan 7.
Published in final edited form as: Pain. 2010 Mar 16;150(1):29–40. doi: 10.1016/j.pain.2010.02.016

Fig. 1.

Fig. 1

Effects of QX-314 and capsaicin on voltage-gated sodium currents (INa) in capsaicin-sensitive TG neurons from adult rats. Representative recordings following the extracellular application of capsaicin alone (1 µM, 1 min) (A), co-application of QX-314 (5 mM) and capsaicin (1 min) after pretreatment by QX-314 alone (B) and co-application of QX-314 and capsaicin (1 min) (C). Upper panel: Long time-base recordings of INa measured during 30-ms voltage steps from a holding potential of −70 mV to a test potential of 0 mV delivered every 10 s. Each vertical deflection indicates INa measured every 10 s. Capsaicin, QX-314 or QX-314 plus capsaicin was applied during the time indicated by the horizontal bar. Lower panel: fast time-base recordings of superimposed sodium current evoked by test pulse at the points indicated in the upper panel. (D) Collected results for the effects of QX-314, capsaicin, or co-application of both on INa in capsaicin-sensitive TG neurons. The numbers in parentheses indicate the number of cells tested. Results are means ± S.E.M. *P < 0.05 compared with the control (INa peak before drug application).