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. Author manuscript; available in PMC: 2016 Jan 7.
Published in final edited form as: Pain. 2010 Mar 16;150(1):29–40. doi: 10.1016/j.pain.2010.02.016

Fig. 4.

Fig. 4

Effect of co-application of capsaicin and QX-314 on INa and APs in TRPV1 knock-out mice. (A) (a) Upper panel: a representative recording following the application or co-application of QX-314 (5 mM) and capsaicin (1 µM, 5 min) in the TRPV1 knock-out mice TG neurons. Lower panel: superimposed INa evoked by test pulse at the points indicated in upper panel. (b) Summary of the effects of QX-314, capsaicin, or co-application of both on INa in TG neurons from TRPV1 knock-out mice. (B) (a) Upper panel: A representative recording following the application or co-application of QX-314 (5 mM) and capsaicin (1 µM, 5 min). Lower panel: APs recorded at the time points indicated at the upper panel. (b) Collected results for the effects of QX-314, capsaicin, or co-application of both on AP amplitude in TRPV1 knock-out mice. TG neurons were small sized (<25 µm in diameter) with a resting membrane potential (Vres) of −54.2 ± 4.6 mV. The numbers in parentheses indicate the number of cells tested. Results are means ± S.E.M.