Increased circulating white blood cell (WBC) counts are associated with enhanced production and survival in DKO mice. (A) Absolute WBCs as means (n = 8–9) + SD. (B) Bone marrow analysis by flow cytometry: LSK populations (Lin−Sca-1+c-Kit+), myeloid progenitor LK cells (Lin−Sca-1−c-Kit+), granulocyte/monocyte progenitors (GMP; Lin−c-Kit+CD34+FcγRII/III+), monocyte/dendritic cell progenitors (MDP; Lin−c-Kit+/IntCD115+Flt3+), common lymphoid progenitors (CLP; Lin−c-KitloSca-1loIL7Rα+). Data represent means (n = 6–7) + SD. (C) Half life of WBCs as means (n = 7) ± SD. *, p < 0.05; **, p ≤ 0.01; ***, p ≤ 0.001.