TABLE 5.
MICs of β-lactams in the presence of a fixed concentration of 5 μg/ml sulbactam
| Drug | MIC50 (μg/ml)a |
MIC90 (μg/ml)a |
Ratio rangeb (%) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| − | + | − | + | 0.031 | 0.062 | 0.125 | 0.25 | 0.5 | 1 | |
| Amoxicillin | 128 | 8 | 256 | 64 | 9 (7.4) | 54 (44.6) | 40 (33.1) | 11 (9.1) | 2 (1.7) | 5 (4.1) |
| Imipenem | 32 | 16 | 128 | 64 | 0 (0.0) | 0 (0.0) | 1 (0.8) | 27 (22.3) | 53 (43.8) | 40 (33.1) |
| Meropenem | 16 | 4 | 32 | 8 | 1 (0.8) | 1 (0.8) | 7 (5.8) | 67 (55.4) | 41 (33.9) | 4 (3.3) |
| Biapenem | 8 | 4 | 32 | 8 | 1 (0.8) | 1 (0.8) | 9 (7.4) | 59 (48.8) | 43 (35.5) | 8 (6.6) |
a
−, Medium supplemented without sulbactam; +, medium supplemented with sulbactam.
b
Ratio represents the MIC value with sulbactam divided by MIC value without sulbactam.