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Relationship between GSK1322322 free drug 24-h AUC (open circles) or AUC/MIC (filled circles) and efficacy against eight S. aureus isolates. Each symbol represents the mean CFU/abscess from five rats. The sigmoid line represents the best-fit curve using a combination of the Emax model and an intermediary model linking PK statistics with dose. R2 is the coefficient of determination.
