TABLE 1.

Summary of polymorphisms and mutations in the FUR1 and FCY2 genes of flucytosine-sensitive and -resistant Candida glabrata clinical isolates

Patient	Polymorphism or mutation in C. glabrata isolatea
	Flucytosine sensitive				Flucytosine resistant
	Genotype		Phenotype		Genotype		Phenotype
	FUR1	FCY2	Fur1p	Fcy2p	FUR1	FCY2	Fur1p	Fcy2p
1	A96G	G369C	R32R	V123V	A96G	G369C	R32R	V123V
	T117C	T468C	S39S	C156C	T117C	T468C	S39S	C156C
	G178G	A915G	WT	L305L	Ins 178–207	A915G	V61Stop	L305L
	T355C		L119L		T355C		L119L
	C370T		L124L		C370T		L124L
	T528C		D176D		T528C		D176D
2	T355C	A693G	L119L	R231R	T355C	A693G	L119L	R232R
	G368G	C813T	WT	A271A	G368T	C813T	E122Stop	A271A
	C370T	G1008A	L124L	V336V	C370T	G1008A	L124L	V336V
	T528C	C1425T	D176D	S475S	T528C	C1425T	D176D	S475S
		T1530A		P510P		T1530A		P510P

^aUnderlined text indicates nucleic acid changes within FUR1 and FCY2 genes compared to the sequences of the reference strain CBS138. Boldface text indicates amino acid changes that occurred as a result of sequence insertion or nucleic acid mutation within the FUR1 gene. WT, wild type.